PE-22-28 Peptide

PE-22-28 is a synthetic analog derived from the endogenous sortilin propeptide, spadin, used in preclinical research to selectively block the TREK-1 potassium channel. It regulates neuronal excitability, synaptic plasticity, and mood-related behaviors in laboratory models. The peptide is produced under GMP-compliant conditions and supplied as a lyophilized powder with full quality documentation including a Certificate of Analysis. It acts as a potent antagonist of TREK-1, enhancing neuronal depolarization and serotonergic neuron activity. Research indicates its role in modulating TREK-1 activity, promoting hippocampal neurogenesis and synaptogenesis, and influencing stress and mood regulation in preclinical studies. It is intended for research use only and not for human use.