FOXO4-DRI Peptide

FOXO4-DRI is a D-amino acid retro-inverso peptide developed by Peter de Keizer’s group at Erasmus MC. It is designed to selectively disrupt the FOXO4-p53 interaction in senescent cells, enabling their targeted clearance while sparing healthy cells in preclinical models. First published in Cell (2017), this peptide has been studied in the context of senolytics, cellular senescence, and longevity research. This research-grade lyophilized peptide is synthesized under strict quality controls and provided with full analytical documentation. For Research Use Only. Not for human use.

Key Scientific Attributes

• High-purity FOXO4-DRI (≥ 99% by HPLC/MS, TFA salt form)
• Verified D-retro-inverso octapeptide sequence: D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg
• Lyophilized formulation for maximum long-term stability
• Full Certificate of Analysis (COA) with HPLC, MS, amino acid analysis, and in vitro p53-binding disruption assay
• Manufactured in GMP-aligned, ISO-compliant facilities
• Suitable for senescent cell clearance studies, FOXO4-p53 interaction research, and cellular senescence investigations

Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims. For research use only.)

• Selectively disrupts FOXO4-p53 nuclear retention, inducing targeted apoptosis of senescent cells in preclinical models, as described by Baar et al., Cell, 2017
• Studied for effects on senescent cell burden in liver, kidney, and muscle tissue in animal models without affecting healthy cells
• Investigated in relation to physical function, fur density, and wound healing endpoints in aged murine models
• No genotoxicity or off-target effects observed in preclinical safety studies
• Used in research related to progeria, sarcopenia, fibrosis, and age-related cellular degeneration models

Why Researchers Choose Nationwide Peptides FOXO4-DRI

• Exact D-retro-inverso sequence used in the original Erasmus MC discovery studies
• Transparent analytical data (HPLC >99%, MS confirmation of D-amino acids)
• Utilized in senolytics and regenerative biology laboratory research
• Competitive research pricing with bulk options

For Research Use Only. Not for human or animal use. All information provided is for educational and laboratory research purposes only.