PNC-27 Peptide

PNC-27 is a synthetic research peptide developed by researchers at SUNY Downstate and NYU, combining the HDM-2-binding domain of p53 (residues 12-26) with a cell-penetrating/membrane residency peptide (MRP). According to published scientific literature, PNC-27 has been shown in preclinical in vitro and in vivo studies to selectively interact with HDM-2 expressed on transformed cell membranes, inducing transmembrane pore formation and cell necrosis in cancer cell lines without affecting untransformed cells (pmc.ncbi.nlm.nih.gov). For Research Use Only. Not for human use.

Key Scientific Attributes

• High-purity PNC-27 (≥98% by HPLC/MS, acetate salt form)
• Verified 32-amino-acid sequence with p53(12-26)-MRP fusion
• Lyophilized formulation for maximum long-term stability
• Full Certificate of Analysis (COA) with HPLC, MS, and amino acid analysis
• Manufactured in GMP-aligned, ISO-compliant facilities
• Intended for HDM-2 membrane targeting, pore formation, and selective cytotoxicity research applications

Research-Referenced Attributes (Based on published scientific literature; for laboratory research reference only. Not intended as therapeutic or health benefit claims.)

• In vitro studies report co-localization with membrane-bound HDM-2 in transformed cell lines (pnas.org)
• Preclinical cell-based assays have investigated activity across multiple transformed cell line models including pancreatic, breast, ovarian, and leukemia lines
• Observed in published literature to co-localize with HDM-2 in transformed cell membranes but not in untransformed cell lines
• Preclinical animal model data published in peer-reviewed literature (pubmed.ncbi.nlm.nih.gov)
• Investigated in combination in vitro research models
• Applicable to solid and hematological tumor cell line models, membrane oncology research, and selective cytotoxicity laboratory studies

Why Researchers Choose Nationwide Peptides PNC-27

• Sequence corresponding to that used in original published SUNY/NYU research studies
• Transparent analytical data (HPLC >98%, MS confirmation)
• Trusted by oncology, membrane biology, and pharmacology laboratories for in vitro research
• Competitive research pricing with bulk options

For Research Use Only. Not for human use. Not for use in animals. Not intended to diagnose, treat, cure, or prevent any disease or condition.